Dosing Memantine is simple, but requires some planning and forethought. It is taken by mouth. Functional enough to play games like Overwatch and keep up with it without any struggle. Memantine 20 mg compared to placebo for mild AD (MMSE 20‐23) observed case (OC) ‐ six‐month studies for dementia. Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [ 41 ]. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. For those who want to use memantine for treating … Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Above 100mg and you'll likely not be moving from your bed/couch very often, although it is possible. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. The memantine dosage will differ based on the use case. The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. I tried memantine a few times and enjoyed it enough, but itâs a weird one, isnât it? Press J to jump to the feed. Super Sour Ketamine is what I would describe the taste as. I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Memantine is used for treatment of moderate-to-severe stage of AD. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. I haven't pushed the limits enough to definitively say it exists. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. Memantine Dosage. The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. I can't compare it to MXE, and it's been a few months since I last had ketamine but I'll do the best I can to explain. I’d recommend slowly exploring higher doses, some of my heroic doses on Memantine have given me experiences I haven’t had on any other drug, and I’ve IM’d 300mg+ ketamine and taken doses as high as 125mg DCK, (on separate occasions) and they still haven’t touched the headspace I’ve reached on Memantine. It has a pretty clear anxiolytic effect on me. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Both the research  and anecdotal reports  recount as much. Dr Andrade takes a closer look at the methods the authors used and the studies they included to weigh the merits of their conclusions. Although there is moderate-certainty evidence that fewer people taking memantine experience agitation as an adverse event: RR 0.81 (95% CI 0.66 to 0.99) (25 fewer people per 1000, 95% CI 1 to 44 fewer), there is also moderate-certainty evidence, from three additional studies, suggesting that memantine is not beneficial as a treatment for agitation (e.g. Just remember that there is no 100% safe drug use. I'm on 20mg daily for mood stabilisation. Ketamine: Much less sedating. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. Visually fairly similar to ketamine, but more controllable. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. Sorry, this post was deleted by the person who originally posted it. What is it with cough suppressants getting us high as shit? Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. And anything else you might like to add. The visuals and euphoria become much more intense and interesting after weed is smoked. 1. When it is working I can think clearly. Structures and voids are very apparent in low light and I would argue go beyond level 4. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Additional information on Memantine can be found: https://psychonautwiki.org/wiki/Memantine, https://www.erowid.org/pharms/memantine/memantine.shtml, Edit: If you've found this post recently, I've made a follow up post, answering some of the frequently asked questions I was receiving after making this post HERE. This will … That being said, Memantine is a beautiful drug. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Take one dose every day, at the same time of day each day. Please comment back on what your experience was like at that dose though. Due to its antagonism of the N-methyl-d-aspartate (NMDA) receptor, which has been shown to block rewarding and reinforcing effects of morphine, memantine has been investigated for potential utilization in … Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. the headspace has much less "static" noise, even compared to being sober. Seems to help my short term memory. This includes: URLs, markets, PMs, etc. Score with placebo (median) Mean improvement in change score between memantine and placebo. Psychonautwiki founder here, you did an amazing job on the mementine article dude. New comments cannot be posted and votes cannot be cast, More posts from the MemantineHCl community. Thanks again dude. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. The new dementia NICE guidelines published in June 2018 state that we should consider memantine for patients with moderate Alzheimer’s Disease and offer memantine for people with severe Alzheimer’s Disease, and if the person is already Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. A sub for discussing all uses of Memantine, from therapeutic to recreational. Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. Use memantine regularly to get the most benefit. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. The high is quite non-intrusive though so it's really best used for a background high I think. I could see some thereputic use in this because of it's functionality and long half life. One interesting memantine side effect includes higher libido. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. I'll explain how some of these play a role in the subjective experience down further. When in doubt, DON'T. 30mg seems to be barely a threshold dose. Is it possible to hole on? I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. This is a risk reduction resource. How long do the effects last? But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. I'm clumsy and stumbling a bit, but I'm able to use a keyboard and phone just fine. We promote harm reduction and fight against the drugs stigma. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? The half-life really makes this unsuited for recreational use imo. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. This means that for memantine to bind, the neuron has to depolarize, and open to clear the magnesium block. Good, comprehensive guide/advice. Make sure you follow the RULES. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. You will be given a small dose when you first start treatment. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. If you over shoot it, it's a very long time to endure it. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. Memantine is a moderate affinity, uncompetitive NMDA receptor antagonist with strong voltage-dependency and fast kinetics. Upwards of 100mg and the dissociation becomes much more apparent, visuals will take form in the way of perceptual changes; depth perception alteration, visual acuity and colour enhancements are some of the most apparent effects. Memantine for dementia – what, why, who and when? Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. Whereas on DXM, it might be too hard to try to play a game. Not using is always safer. Thanks! Preface. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). TL;DR: Memantine has a high potential for recreational use. It's heavily memory impairing for a few minutes, and fairly confusing at high doses. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. Adding the Alzheimer drug memantine to a selective serotonin reuptake inhibitor (SSRI) may improve depressive symptoms, as well as apathy, anxiety, and cognitive function, in older patients. I'm super happy I'm not the only one around here using it like this. You need to leave yourself at least 12 hours before you want to sleep before dosing. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. The mean age of patients who were receiving memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively. Insufflation works, has a slightly faster onset but is fairly painful. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Memantine changed my life, therapeutic use fixed my depression, stopped me from compulsively using Ketamine to treat it, and has given me a quality of life I had only dreamed of, and I get to trip on it once in a while too. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. User Reviews for Memantine. Memantine is een geneesmiddel dat geregistreerd is voor de behandeling van patiënten met een matige tot ernstige vorm van de ziekte van Alzheimer.Het behandelt de oorzaak van de ziekte niet maar het laat toe dat patiënten misschien wat langer zelfstandig kunnen functioneren. The physical euphoria is almost like a soft buzzing, underneath the skin, most noticably in the hands, toungue, scalp, and behind the legs. And for the most part I'm perfectly functional cognivitely. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Sweet write up, it sounds like an interesting drug worth experiencing. It is less preferred than acetylcholinesterase inhibitors such as donepezil. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … I can't explain much further, simply because I can't remember what happens when I do it. I want to bring it to light as the amazing drug it is. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of … Memantine seems less debilitating than that of Ketamine or DXM. Press question mark to learn the rest of the keyboard shortcuts. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). Memantine is on my bucket list, I really hope I get the chance to try it someday. Then memantine is pulled into the channel to its binding site. It's clean feeling, compared to DXM. Results were inconclusive because of studies with poor levels of … That way, memantine is eliminated 7-10 times faster. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Never heard of this drug before. I have just awoken at 90+ hours, and I think I'm finally pretty much back to baseline. Ive had minimal unwanted physical side effects. Nice trip report. It doesn't appear in any feeds, and anyone with a direct link to it will see a message like this one. New comments cannot be posted and votes cannot be cast. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. With the CAGR of X.X%, this market is estimated to reach USD XX million in 2026. Memantine was not effective at reducing cognitive deficits, and patients who tried memantine had more adverse effects such as fatigue . If it isn't apparent guys, I have a lot of spare time. Namenda (memantine): “My PCP put me on Namenda to supplement my Aricept for Alzheimer's Disease . I have a few questions regarding its effects however. Population: mild Alzheimer's disease Intervention: memantine 20 mg Comparison: placebo . And personally I enjoy it a lot. Common side effects … 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. Press question mark to learn the rest of the keyboard shortcuts. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. However my memory lapses happen every 2 weeks or so and only for a short period. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. Memantine is a prescription drug that is also known by the brand name Namenda. However, the drug does not cure Alzheimer’s. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. How much does it help? Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Do you have any previous experience with dissociatives, and if so how do they compare? After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. 2019 One meta-analysis showed that there was a significant improvement in cognitive function in AD patients who took memantine. From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. Memantine is commonly used for the treatment of moderate-to-severe Alzheimer's disease. Store memantine at room temperature away from moisture and heat. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. Get your prescription refilled before you run out of medicine completely. Treatment should only be continued if beneficial effects are seen. There are over-the-counter medications available to acidify the urine too; for example, pills containing methionine, which is used to prevent bladder infections.' Memantine is great. Reddit; Wechat; To the Editor, We read with interest the papers by Brenner 1 and Cimolai 2 regarding the therapeutic potential of memantine for coronavirus disease 2019 (COVID‐19). One around here using it like this one how it helped your depression part memantine... Dementia in Alzheimer 's disease if you over shoot it, it 's available on clearnet... 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